It was determined that 5 lung adenocarcinoma oncogens are mutually exclusive and present in more than 50% of adenocarcinoma cases. The oncogenes include KRAS, EGFR, ALK, ERBB2, and BRAF. KRAS mutations are the most common ones; it is responsible for encoding GTPase that is able to send signals when GTP bound through RAF and ERK (Greulich, 2011; Jackma... read more
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